Correction for “ Core epithelial - to - mesenchymal transition in - teractome gene - expression signature is associated with claudin - low and metaplastic breast cancer subtypes
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چکیده
CELL BIOLOGY Correction for “Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudinlow and metaplastic breast cancer subtypes,” by Joseph H. Taube, Jason I. Herschkowitz, Kakajan Komurov, Alicia Y. Zhou, Supriya Gupta, Jing Yang, Kimberly Hartwell, Tamer T. Onder, Piyush B. Gupta, Kurt W. Evans, Brett G. Hollier, Prahlad T. Ram, Eric S. Lander, Jeffrey M. Rosen, Robert A. Weinberg, and Sendurai A. Mani, which appeared in issue 35, August 31, 2010 of Proc Natl Acad Sci USA (107:15449–15454; first published August 16, 2010; 10.1073/pnas.1004900107). The authors note that on page 15453, right column, fifth full paragraph, sentence 2, “Microarray data for HMLE Gsc, Snail, Twist, TGF-β1, and vector control has been deposited in GEO under accession number GSE9691” should instead appear as “Microarray data for HMLE Gsc, Snail, Twist, TGF-β1, and vector control has been deposited in GEO under accession number GSE24202.”
منابع مشابه
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes.
The epithelial-to-mesenchymal transition (EMT) produces cancer cells that are invasive, migratory, and exhibit stem cell characteristics, hallmarks of cells that have the potential to generate metastases. Inducers of the EMT include several transcription factors (TFs), such as Goosecoid, Snail, and Twist, as well as the secreted TGF-beta1. Each of these factors is capable, on its own, of induci...
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There is increasing evidence that breast and other cancers originate from and are maintained by a small fraction of stem/progenitor cells with self-renewal properties. Recent molecular profiling has identified six major subtypes of breast cancer: basal-like, ErbB2-overexpressing, normal breast epithelial-like, luminal A and B, and claudin-low subtypes. To help understand the relationship among ...
متن کاملThe Difference of Expression of 18 Genes in Axillary Invasion and Vascular Invasion Compared to Control Samples in Breast Cancer
Background & Objective: Recent studies from gene profiling have revealed some genes that are overexpressed in the epithelial-mesenchymal transition (EMT) process and are responsible for its initiation and activation resulting in tumor progression and metastasis. The present study aimed to assess the role of genes involved in the EMT process and the association of these genes wi...
متن کاملCharacterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics.
Metaplastic breast cancers (MBC) are aggressive, chemoresistant tumors characterized by lineage plasticity. To advance understanding of their pathogenesis and relatedness to other breast cancer subtypes, 28 MBCs were compared with common breast cancers using comparative genomic hybridization, transcriptional profiling, and reverse-phase protein arrays and by sequencing for common breast cancer ...
متن کاملAnalysis of epithelial mesenchymal transition markers in breast cancer cells in response to stromal cell-derived factor 1
Introduction: Metastasis is the main cause of cancer death; however, the underlying mechanisms of metastasis are largely unknown. The chemokine of stromal cell-derived factor 1 (SDF1) and the process of epithelial mesenchymal transition (EMT), both have been declared as important factors to promote cancer metastasis; however, Conspicuously, the relation between them has not been recognized well...
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تاریخ انتشار 2010